Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,231-1,240 of 2,298 results
Frontiers in Veterinary Science, 2023 • July 13, 2023
This study evaluated the efficacy of intensive neurorehabilitation combined with mesenchymal stem cell transplantation (INSCP) in dogs with degenerative myelopathy (DM). The study found that the INSCP...
KEY FINDING: The INSCP group (intensive neurorehabilitation with stem cells) had a mean survival time of 438 days, compared to 274 days for the ARP group (ambulatory rehabilitation protocol).
eLife, 2023 • August 3, 2023
The present study showed that ALKBH5 plays a critical role in axonal regeneration after nerve injury. The ALKBH5 protein level was reduced in DRG neurons following SNC, which enhanced neurite outgrowt...
KEY FINDING: Knockdown of ALKBH5 enhanced sensory axonal regeneration, whereas overexpressing ALKBH5 impaired axonal regeneration in an m6A-dependent manner.
Theranostics, 2023 • July 24, 2023
This review highlights engineering strategies for exosomes and their delivery routes in neural research, emphasizing theranostic applications in peripheral nerve, traumatic spinal cord, and brain inju...
KEY FINDING: Engineering exosomes through pretreatment of progenitor cells can regulate their contents and enhance their bioactivity, leading to improved therapeutic outcomes in nerve regeneration.
Theranostics, 2023 • July 9, 2023
This review introduces the pathological changes of eNSPCs and their microenvironment after SCI. It focuses on strategies developed to stimulate eNSPC neurogenesis and relieve inhibiting elements, part...
KEY FINDING: The post-SCI microenvironment promotes the proliferation and astrocyte differentiation of eNSPCs, contributing to glial scar formation.
Annals of Medicine & Surgery, 2023 • July 3, 2023
Stem cell-based combinatorial therapies offer a promising avenue for treating spinal cord injuries (SCI) by combining stem cells with other therapeutic approaches. Preclinical studies have demonstrate...
KEY FINDING: Stem cell-based combinatorial therapies have shown promise in preclinical studies for SCI. Incorporating therapeutic strategies such as rehabilitation, growth factors, and biomaterials has demonstrated potential in animal models.
Exp Neurol, 2023 • October 1, 2023
First, we have replicated that delivery of AAVrg’s can exert a wide genetic influence throughout the neuroaxis when applied rostral to an SCI lesion but that transduction efficacy within the caudal Ra...
KEY FINDING: PTEN-KO using AAVrg’s improves locomotor outcomes in both acute and chronic SCI conditions, however, the effects are severity dependent.
Nature Communications, 2023 • August 8, 2023
This study examines the role of H3K9me3 reprogramming during early development of SCNT embryos, revealing defective H3K9me3 reprogramming during SCNT embryogenesis. The researchers found that persiste...
KEY FINDING: SCNT embryos exhibit genome-wide excess H3K9me3 modification throughout preimplantation development, differing significantly from fertilized embryos.
Nature Communications, 2023 • August 11, 2023
This study identifies Hb-egf as a neurogenic factor essential for spinal cord regeneration in zebrafish, highlighting its role in ERG cycling and neuron production. The research uncovers a TREE (hb-egf...
KEY FINDING: Hb-egfa is a neurogenic factor necessary for innate spinal cord regeneration in zebrafish.
Polymers, 2023 • July 26, 2023
This study evaluates the effectiveness of combining surgical repair with a fibrin biopolymer and dimethyl fumarate (DMF) treatment for spinal root avulsion in rats. Ventral root avulsion (VRA) in rats...
KEY FINDING: The combination of fibrin biopolymer and dimethyl fumarate is neuroprotective, preserving synapses near motoneurons.
Journal of Neurotrauma, 2023 • December 1, 2023
This study investigates the long-term anatomical outcomes of neural progenitor cell (NPC) transplantation in mice with spinal cord injuries, comparing early (8 weeks) and far (26 weeks) chronic time p...
KEY FINDING: Graft neuronal density does not significantly change over time, indicating stable neuron numbers within the transplant.