Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,221-1,230 of 2,298 results
Cells, 2023 • June 22, 2023
This review provides a comparative analysis of spinal cord injury in both non-regenerating (mammals) and regenerating animals (axolotl, Xenopus, zebrafish), focusing on the epigenetic mechanisms under...
KEY FINDING: In mammals, axonal regrowth after a spinal cord injury is hindered by the development of a glial scar that mainly consists of reactive astrocytes and proteoglycans.
Int. J. Mol. Sci., 2023 • June 25, 2023
This study investigates the role of KDM6B in the neurogenesis potential of stem cells from the apical papilla (SCAPs) and its impact on spinal cord injury (SCI) recovery. The findings suggest that KDM...
KEY FINDING: KDM6B inhibits the expression of neural markers like NeuroD, TH, β-III tubulin, and Nestin in SCAPs.
Int. J. Mol. Sci., 2023 • June 30, 2023
This study investigates the transcription patterns of neurotrophins and their receptors in the adult zebrafish spinal cord, using qPCR and in situ hybridization techniques. The results indicate that n...
KEY FINDING: Ngf mRNA is highly expressed in the spinal cord compared with the brain, and it is the most expressed transcript in the whole adult zebrafish spinal cord, compared to other neurotrophic factors.
Int. J. Mol. Sci., 2023 • June 30, 2023
The study investigated the therapeutic potential of co-administering resolvin D1 (RvD1) and peripheral nerve-derived stem cell (PNSC) spheroids in a rat model of spinal cord injury (SCI). In vitro ana...
KEY FINDING: Combined therapy of RvD1 and PNSC spheroids outperformed monotherapies, exhibiting enhanced neuronal regeneration and anti-inflammatory effects.
Neural Regeneration Research, 2023 • December 1, 2023
This study investigates the role of fidgetin (Fign), a microtubule-severing enzyme, in axonal regeneration after spinal cord injury (SCI). The researchers found that depleting Fign enhances axon regen...
KEY FINDING: Depletion of fidgetin enhances axon regeneration after spinal cord injury and increases the expression of end binding protein 3 (EB3).
Neural Regeneration Research, 2023 • December 1, 2023
This research explores the transcriptomic changes during spinal cord regeneration in Cynops orientalis following injury, identifying differentially expressed genes at acute (4 days) and subacute (7 da...
KEY FINDING: 13,059 genes were differentially expressed during C. orientalis spinal cord regeneration compared with uninjured animals, with 4273 continuously down-regulated and 1564 continuously up-regulated.
Neural Regeneration Research, 2023 • April 10, 2023
This study investigates the role of RhoA in dendrite degeneration and regeneration following brachial plexus injury in mice. Motor neuron-specific RhoA knockout mice were created to assess the impact ...
KEY FINDING: RhoA knockout in motor neurons attenuates dendrite degeneration after brachial plexus transection, as evidenced by higher dendrite density and reduced fragmentation in knockout mice compared to controls.
Bioactive Materials, 2023 • June 19, 2023
Neurodegenerative diseases present a growing burden on healthcare systems, necessitating effective treatments. Mesenchymal stem cells (MSCs) show promise due to their neuroregenerative, neuroprotectiv...
KEY FINDING: MSC-secretome and EVs have shown potential in improving cognitive decline, reducing plaque deposition, regulating inflammatory responses, and decreasing neuronal degeneration in Alzheimer's disease models.
Frontiers in Molecular Neuroscience, 2023 • July 10, 2023
This study tracked swim function in zebrafish before and after spinal cord injury, correlating it with anatomical regeneration. Rostral compensation was identified as a key gait feature associated wit...
KEY FINDING: Rostral compensation, a new gait quality metric, is highly correlated with functional recovery in zebrafish after spinal cord injury.
Curr Opin Genet Dev, 2023 • October 1, 2023
Recent evidence suggests that in vivo fate reprogramming of resident cells that are normally non-neurogenic can generate new neurons. This process also improves the pathological microenvironment, and ...
KEY FINDING: Biomaterial-elicited neurogenesis from resident NSCs could provide a much-needed therapeutic strategy for patients with severe SCI.