Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,211-1,220 of 2,298 results
Neural Regeneration Research, 2023 • March 31, 2023
This study demonstrated the neuroprotective role of Rheb in promoting axon regeneration and increasing RGC survival after ONC. Overexpression of caRheb in RGCs activated the mTORC1 pathway, leading to...
KEY FINDING: Overexpression of constitutively active Rheb promoted survival of retinal ganglion cells in the acute (14 days) and chronic (21 and 42 days) stages of injury.
Advanced Science, 2023 • June 9, 2023
This study investigates the therapeutic potential of human neural stem cells (hNSCs) with reduced SOX9 expression for treating spinal cord injury (SCI). The researchers found that hNSCs with approxima...
KEY FINDING: Half dose of SOX9 in hPSCs-derived NSCs (hNSCs) results in robust neuronal differentiation bias toward motor neuron lineage.
Cells, 2023 • May 25, 2023
The study demonstrates a method for generating fate-committed Schwann cells from human bone marrow stromal cells (hBMSCs) using induced pluripotent stem-cell-derived sensory neurons (hiSNs). Transplan...
KEY FINDING: hBMSC-dSCs, when transplanted into rats with sciatic nerve injuries, significantly improved gait compared to controls, suggesting nerve regeneration.
Cellular and Molecular Life Sciences, 2023 • June 17, 2023
The study investigated the persistence of ependymal cells in the human spinal cord during aging, examining spinal cords from 17 organ donors aged 37-83 years. The findings demonstrate that ependymal c...
KEY FINDING: FOXJ1+ cells, co-expressing SOX2 and PAX6, persist in the central region of the spinal cord throughout human life, even in donors aged 37-83 years.
Biomed J Sci Tech Res, 2022 • July 1, 2022
Neuroinflammation is a key secondary event after spinal cord injury (SCI) that can hinder nerve regeneration. Immunomodulatory strategies that limit inflammatory responses offer potential therapeutic ...
KEY FINDING: Gene therapy can provide long-term sustained expression of therapeutic genes to modulate the inflammatory response after SCI, with viral vectors like lentivirus and adeno-associated virus being less immunogenic than adenovirus.
Science Advances, 2023 • June 23, 2023
This study reports a hybrid hydrogel made from a small functional self-assembling peptide (F-SAP) and large silk fibroin (SF) for treating spinal cord injury (SCI). The F-SAP/SF hybrid hydrogel couple...
KEY FINDING: The F-SAP/SF hybrid hydrogel coupled with controlled release of NT-3 provided a permissive environment for neural regeneration.
Signal Transduction and Targeted Therapy, 2023 • July 7, 2023
This review outlines the epidemiology and pathophysiology of SCI, detailing recent progress in neural regeneration and circuit reconstruction, and suggesting future directions for SCI repair and clini...
KEY FINDING: Single-cell RNA sequencing has identified latent lineage potential in neural stem cells (NSCs) in the spinal cord's ependymal region to differentiate into oligodendrocytes by regulating OLIG2 expression.
Int. J. Mol. Sci., 2023 • June 16, 2023
This study introduces a novel OPF hydrogel scaffold with ridges and a TiSAMP surface, designed to promote nerve regeneration after spinal cord injury. The in vitro results show the scaffold supports c...
KEY FINDING: OPF sheets with ridges and TiSAMP chemical patterns promote alignment and outgrowth of cells, and also influence the directionality of the produced ECM, which could aid in nerve regeneration.
bioRxiv, 2023 • June 15, 2023
This study reveals that glia reprogramming induces robust regeneration of CST axons and 5-HT axons across the lesion after SCI. NG2 glia reprogramming by SOX2 produces not only new neurons but also an...
KEY FINDING: NG2 glia reprogramming induces robust regeneration of CST axons after SCI, with axons extending as far as 2.6 mm caudal to the lesion center.
Stem Cell Research & Therapy, 2023 • June 2, 2023
An orchestrated modulation of gene expression profiles (affecting transcription factors, cell adhesion molecules, receptors, and ion channels) occurs during the transition of ependymal cells from unin...
KEY FINDING: SCI induces the re-localization of E-cadherin to the cytosol and circumferential membrane.