Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,201-1,210 of 2,298 results
Stem Cell Reports, 2023 • May 9, 2023
The study investigates the behavior of transplanted human retinal organoid cells in photoreceptor-deficient mice. It examines how the recipient retina affects the survival, maturation, and proliferati...
KEY FINDING: Human cells transplanted into mice retinas migrated into all retinal layers, identified as astrocytes and brain/spinal cord-like neural precursors.
Am J Case Rep, 2023 • May 13, 2023
This case report details the treatment of a 37-year-old male with a chronic complete spinal cord injury using intrathecal injections of Wharton’s Jelly-derived mesenchymal stem cells (WJ-MSCs). The tr...
KEY FINDING: The patient's ASIA grade improved from A to C, indicating an improvement in neurological function.
World Journal of Urology, 2023 • May 17, 2023
This study investigates the safety and feasibility of using spider silk for erectile nerve reconstruction during robot-assisted radical prostatectomy (RARP). Six patients underwent RARP with spider si...
KEY FINDING: Spider silk nerve reconstruction (SSNR) during robot-assisted radical prostatectomy is feasible and does not cause major complications.
Communications Biology, 2023 • May 2, 2023
The study investigates how the developmental stage of transplanted neural progenitor cells (NPCs) affects anatomical and functional outcomes after spinal cord injury (SCI) in mice. Results indicate th...
KEY FINDING: Earlier-stage NPC grafts (E11.5) exhibited greater axon outgrowth, enrichment for ventral spinal cord interneurons and Group-Z spinal interneurons, and enhanced host 5-HT+ axon regeneration compared to later-stage grafts.
Front. Cell Dev. Biol., 2023 • May 9, 2023
This article examines the history of lampreys in neurobiology since the 1830s, emphasizing their role in spinal cord regeneration research after 1959. The large nerve cells and basal evolutionary posi...
KEY FINDING: Functional recovery in lampreys after spinal cord injury can occur through imperfect axonal regrowth and compensatory plasticity.
Biology, 2023 • April 26, 2023
Spinal cord injury (SCI) represents a significant medical challenge, often resulting in permanent disability and severely impacting the quality of life for affected individuals. In recent years, multip...
KEY FINDING: MSCs secrete a variety of growth factors and cytokines that exhibit neuroprotective effects, playing a pivotal role in supporting the recovery of damaged neurons after SCI.
Biomedicines, 2023 • April 30, 2023
This study demonstrates that intravenous infusion of autologous genetically enriched leucoconcentrate can positively impact targets distant from the primary spinal cord injury site in mini pigs. The g...
KEY FINDING: The autologous genetically enriched leucoconcentrate promoted positive remodeling of macro- and microglial cells in the lumbar spinal cord of treated mini pigs.
Biomedicines, 2023 • May 12, 2023
This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results...
KEY FINDING: hASCs combined with heparin-based hydrogel micropatches enhanced nerve regeneration in a neuropathic pain animal model.
Experimental & Molecular Medicine, 2023 • June 1, 2023
This study investigates the therapeutic potential of human urine-derived induced neural stem cells (iNSCs) in rat models of spinal cord injury (SCI). The researchers successfully generated iNSCs from ...
KEY FINDING: iNSCs derived from human urine cells can survive, engraft, and differentiate into neurons and glial cells when transplanted into injured spinal cords of rats.
The Journal of Neuroscience, 2023 • June 28, 2023
This study was designed to study the mRNA profile of sensory neurons whose axons, driven by a9 integrin and kindlin-1, were regenerating in the spinal cord. Expression of integrin and kindlin drives s...
KEY FINDING: Expression of a9k1 without the central axotomy led to upregulation of a known PNS regeneration program, including many genes associated with peripheral nerve regeneration.