Regenerative Medicine Research

KEY FINDING: VD11 promotes the secretion of NGF and BDNF in BV2 cells stimulated with lipopolysaccharide, as well as the proliferation and synaptic elongation of PC12 cells subjected to hypoxia.

KEY FINDING: AP-EXOR&L&S enables its homing competency to SCI injury sites where multifunctional peptide-loaded AP-EXO exerted their potential effect on SCI repair by directly targeting the lesion sites.

KEY FINDING: The study found that research on stem cell therapy for spinal cord injury has been increasing since 2000. Neural Regeneration Research was the journal with the most publications and the fastest cumulative publication growth.

KEY FINDING: RPS6 phosphorylation on Ser235-236 is essential for PNS and CNS regeneration in mice.

KEY FINDING: LIPUS stimulation effectively promoted the expression of mature cartilage-related genes and proteins and inhibited TNF-α gene expression in hUC-MSCs.

KEY FINDING: Basic research indicates PRP has promising regenerative potential for intervertebral disc degeneration based on in vitro and in vivo studies.

KEY FINDING: Recombinant gthrombin showed super-high catalytic and fibrinogenolytic efficiency compared to human thrombin under various temperature and pH conditions.

KEY FINDING: The study identifies distinct subpopulations of GFAP-expressing cells with unique functional enrichment and identities defined by subpopulation-specific transcription factors and regulons.

KEY FINDING: PS18 promoted the formation of a neuroectodermal covering over the defective neural tube within 24-h after treatment, enhancing regeneration and decreasing apoptotic activity.

KEY FINDING: miR-221-3p expression decreases sharply in the SNCI group compared with the simple dorsal column lesion (SDCL) group, suggesting its involvement in nerve regeneration.