Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,181-1,190 of 2,298 results
Bioeng Transl Med, 2023 • March 1, 2023
This study introduces a novel centimeter-scale human spinal cord neural tissue (hscNT) construct composed of human spinal cord neural progenitor cells (hscNPCs) and human spinal cord astrocytes (hscAS...
KEY FINDING: Human spinal cord astrocytes (hscAS) promote the adhesion, survival, and neurite outgrowth of human spinal cord neural progenitor cells (hscNPCs) on a linearly ordered collagen scaffold (LOCS).
NEURAL REGENERATION RESEARCH, 2023 • January 5, 2023
This study investigates the effect of CXCR7 antibody on neural plasticity after ischemic stroke in rats. The researchers found that CXCR7 antibody increased axonal regeneration, synaptogenesis and mye...
KEY FINDING: CXCR7-neutralizing antibody increased the total length and number of sprouting corticospinal tract fibers in rats with cerebral ischemia, indicating enhanced axonal regeneration.
Cell Regeneration, 2023 • March 2, 2023
This study successfully differentiated hPSCs into self-renewal hSCNPCs through hNMPs, expressing homogeneous pan-NPC markers and spinal cord specific markers. The hSCNPCs could be further differentiat...
KEY FINDING: The study established a protocol for generating hSCNPCs from hPSCs through high-purity hNMPs, showing molecular properties of the spinal cord.
Stem Cell Research & Therapy, 2023 • March 13, 2023
This study investigates the effects of cytokines released from inflammation-stimulated astrocytes on the differentiation of NSCs following SCI and explores the influence of these cytokines on NSC–NSC ...
KEY FINDING: Inflammatory stimulation of astrocytes increases BMP2 release, promoting NSC differentiation into astrocytes and inhibiting axon remyelination in SCI lesions.
Cells, 2023 • March 9, 2023
Spinal cord injury (SCI) leads to detrimental cellular processes, including axonal degeneration, neuronal loss, neuroinflammation, reactive gliosis, and scar formation. The glial scar border forms to ...
KEY FINDING: The glial scar, composed of astrocytes, fibroblasts, and microglia, forms a physicochemical barrier that isolates inflammation but also inhibits neural regeneration.
J. Pers. Med., 2023 • February 28, 2023
This study evaluated the usefulness of motor potentials evoked transvertebrally at lumbar levels in assessing peroneal nerve regeneration in rats after experimental repair. Recordings were performed 2...
KEY FINDING: MEP and ENG stimulations both resulted in evoked potentials, with larger amplitude values following the application of magnetic pulses.
Frontiers in Bioengineering and Biotechnology, 2023 • March 14, 2023
This study introduces hp-SHED sheet, a bioactive material mimicking the spinal cord microenvironment, to promote nerve regeneration in SCI rats. The hp-SHED sheet possesses a porous structure facilita...
KEY FINDING: Hp–SHED sheet has a porous three-dimensional inner structure, which facilitates nerve cell attachment and migration.
Expert Opin Ther Targets, 2023 • March 1, 2023
Clinical treatments for SCI are currently unavailable, creating a need for effective repair strategies. Recent research has advanced the understanding of SCI pathophysiology and identified new preclin...
KEY FINDING: Numerous strategies are being explored to reduce secondary injuries after SCI by targeting mechanisms like excitotoxicity, oxidative stress, inflammation, and cell death.
Scientific Reports, 2023 • April 4, 2023
This study investigates the potential of resveratrol (Res) to enhance the therapeutic efficacy of adipose-derived stem cells (ADSCs) in promoting sciatic nerve regeneration in rats. The findings demon...
KEY FINDING: Resveratrol pretreatment significantly improved H2O2-induced apoptosis in ADSCs in vitro, as confirmed by the TUNEL assay and the expression levels of apoptosis-related proteins (caspase-3, Bax, and Bcl-2).
Int. J. Mol. Sci., 2023 • March 30, 2023
This review underscores the critical role of macrophages and their subpopulations in tissue repair and regeneration, focusing on their secretion of TNF-α, which promotes axonal regeneration in zebrafis...
KEY FINDING: Macrophages and their subpopulations play a crucial role in tissue repair and regeneration, focusing on their secretion of TNF-α, which promotes axonal regeneration in zebrafish.