Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,031-1,040 of 2,298 results
Bioactive Materials, 2022 • January 1, 2022
The study developed an Aga/Gel/PPy (AGP3) hydrogel with similar conductivity and modulus as the spinal cord. The physically crosslinked features made the AGP3 hydrogels injectable. In vitro cultures s...
KEY FINDING: AGP3 hydrogel exhibits excellent biocompatibility, promoting neural stem cell differentiation towards neurons while inhibiting astrocyte over-proliferation.
JOR Spine, 2022 • January 1, 2022
Intradiscal injection is a minimally invasive technique used for low back pain, with its safety and effectiveness supported by clinical trials. Various medications and biological agents are used, but ...
KEY FINDING: Intradiscal injection is a minimally invasive outpatient procedure that can improve pain quality for patients with LBP or lumbar disc herniation (LDH).
The Journal of Neuroscience, 2022 • April 6, 2022
Peterson et al. (2021) characterized the roles of C3, C1q, and CR3 during axon regeneration in a model of optic nerve injury in mice, finding that C1q, C3, and CR3 are required for regeneration. The r...
KEY FINDING: C3 expression rapidly increased in the optic nerve after crush injury, followed by a steady increase in C1q expression. CR3+ cells increased from 1 day post-injury up to 14 days.
Scientific Reports, 2022 • April 8, 2022
This study investigated the miRNA profiles of human umbilical cord blood mesenchymal stem cells (CB-MSCs) during their differentiation into motor neuron-like cells using retinoic acid (RA) and sonic h...
KEY FINDING: MiR-9-5p and miR-324-5p were significantly up-regulated in cells treated with retinoic acid (RA) and sonic hedgehog (Shh), suggesting their involvement in early motor neuron differentiation. The analysis of miRNA sequencing demonstrated a significant up-regulation of miR-9-5p and miR-324-5p in Test 1 (RA + /Shh +).
Exp Neurol, 2022 • July 1, 2022
The study identifies Rph3a as a Rab GTPase effector that limits axon regeneration in the adult mammalian CNS. After axotomy, there is increased association of Rph3a with ß1-containing integrins, and t...
KEY FINDING: Rabphilin3A interacts with Rab27b and regulates axon regeneration in cortical neurons.
Cells, 2022 • March 28, 2022
This study combined mesenchymal stromal cells (MSCs) and a nanofiber-hydrogel composite (NHC) to assess their repair effects in the contused spinal cord in adult rats. The data support further study in...
KEY FINDING: Treatment with MSC-NHC or NHC alone significantly attenuated early macrophage infiltration in the contusion compared to MSC-PBS, indicating a reduced initial inflammatory response.
Bioactive Materials, 2022 • January 1, 2022
This study introduces an anti-CD29 antibody-conjugated small intestine submucosa (AC-SIS) scaffold designed to capture urine-derived stem cells (USCs) in situ for bladder repair and regeneration. In v...
KEY FINDING: The AC-SIS scaffold exhibited effective capture capacity of urine-derived stem cells (USCs) in vitro.
Cellular and Molecular Life Sciences, 2022 • April 13, 2022
Spinal cord injury induces mitochondrial dysfunction, resulting in ROS generation, loss of bioenergetics, and cell death, that together with the initial damage, induce a switch towards a glycolytic me...
KEY FINDING: Mitochondrial dysfunction is a common event in different triggers leading to cell death after SCI.
Frontiers in Pharmacology, 2022 • March 31, 2022
This study investigated the therapeutic potential of SHED-CM for neuropathic pain (NP) using a mouse model of partial sciatic nerve ligation (PSL). The results showed that SHED-CM effectively reduced ...
KEY FINDING: Intravenous administration of SHED-CM greatly improved PSL-induced hypersensitivity, indicating a reduction in neuropathic pain symptoms in mice.
The Journal of Neuroscience, 2022 • May 18, 2022
The study demonstrates that NogoA, an NgR1 ligand, regulates commissural axon guidance in the chicken spinal cord. Live imaging shows that interfering with the Nogo/NgR1 pathway alters commissural axo...
KEY FINDING: Loss of either NgR1 or NgR3 causes commissural axons to stall in the midline area and interferes with the rostral turn of postcrossing axons in the developing chicken spinal cord.