Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,021-1,030 of 2,298 results
NEURAL REGENERATION RESEARCH, 2022 • October 1, 2022
This review discusses the critical roles of the mTOR pathway in axon regeneration in different types of CNS injury and demonstrates that the reactivation of this regenerative pathway can be achieved b...
KEY FINDING: mTOR signaling is the intrinsic axon regenerative pathway, and its reactivation can promote axon regeneration after adult CNS injury.
Asian Journal of Pharmaceutical Sciences, 2022 • January 1, 2022
Spinal cord injury (SCI) is a complex condition with limited effective treatments. Stem cell transplantation, particularly using mesenchymal stem cells (MSCs), has emerged as a promising therapeutic s...
KEY FINDING: Biomaterial scaffolds, such as those made from collagen, hyaluronic acid (HA), or gelatin, can support MSC growth, maintain cell viability, and confine their distribution within the injured spinal cord.
Frontiers in Molecular Neuroscience, 2022 • February 23, 2022
Spinal cord injury (SCI) results in multiple pathophysiological processes, including blood–spinal cord barrier disruption, hemorrhage/ischemia, oxidative stress, neuroinflammation, scar formation, and ...
KEY FINDING: Stimulating intracellular cAMP activity significantly promotes neuronal survival and axonal regrowth after SCI.
Cellular & Molecular Biology Letters, 2022 • March 14, 2022
The study investigates the therapeutic potential of IL10-modified MSCs in a mouse model of SCI. IL10-MSCs were generated and assessed for safety and efficacy, showing improved motor function recovery ...
KEY FINDING: IL10-MSC treatment markedly reinforced locomotor improvement, accompanied with decreased lesion volume, regeneration of axons, and preservation of neurons, compared with naïve unmodified MSCs.
Journal of Neuroinflammation, 2022 • March 1, 2022
This study investigates the role of NLRP3 inflammasome activation in sciatic nerve injury, focusing on motoneurons, microgliosis, and regeneration. The central reaction to sciatic nerve injury begins ...
KEY FINDING: NLRP3 inflammasome components are markedly upregulated in the L4–L5 segments of the spinal cord in the first 3 days after sciatic nerve injury.
Dev Dyn, 2022 • June 1, 2022
Axolotls are valuable models for developmental and regenerative research, possessing the unique ability to regenerate most tissues well into adulthood. The sequencing of the axolotl genome and the dev...
KEY FINDING: Axolotls exhibit scarless wound healing and have a lower incidence of cancer, making them valuable for cell plasticity studies.
Biomedicines, 2022 • March 15, 2022
This study explores the therapeutic potential of hEpi AD–MSC exosomes for spinal cord injury (SCI) in rats. Exosomes were isolated, characterized, and administered intravenously to SCI-induced rats. R...
KEY FINDING: hEpi AD–MSC exosomes improved the locomotor function of SCI-induced rats, as measured by the BBB locomotor scale.
Pharmaceutics, 2022 • March 9, 2022
This study introduces Bio-C, a novel biocompatible and biodegradable material composed of modified hyaluronic acid-coated collagen, for spinal cord injury (SCI) repair. In vivo experiments on mice wit...
KEY FINDING: Bio-C implantation resulted in better hind-limb recoveries in mice after SCI, compared to controls, as measured by BMS scores.
Frontiers in Cell and Developmental Biology, 2022 • March 8, 2022
This review focuses on ATF3, a transcription factor that is emerging as a conserved pro-regenerative factor across vertebrates, particularly in the nervous system. ATF3 is consistently induced in neur...
KEY FINDING: ATF3 protein is highly conserved across vertebrate species, suggesting it may share similar functions in the nervous system.
The Journal of Neuroscience, 2022 • May 4, 2022
This study demonstrates the critical role of neuronal DLK and LZK in axonal repair including both regeneration and sprouting in the mammalian spinal cord. DLK/LZK-dependent injury signaling and PTEN/m...
KEY FINDING: The inducible neuronal deletion of both DLK and LZK, but not either kinase alone, abolishes PTEN deletion-induced regeneration and sprouting of CST axons.