Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,011-1,020 of 2,298 results
Clinics, 2022 • January 1, 2022
This study evaluated the effects of GM1 ganglioside and erythropoietin, both individually and combined, on functional and immunohistochemical outcomes in mice with experimental spinal cord injury (SCI...
KEY FINDING: GM1 alone led to the highest scores on the BMS and MFS scales, indicating better functional recovery compared to erythropoietin alone or the combination.
Cells, 2022 • February 9, 2022
IVD degenerative disease is a major obstacle to independent and healthy living and an important issue that needs to be addressed and overcome. A number of studies have been performed on cell-based IVD...
KEY FINDING: Cell-based therapies, such as transplanting autologous NP-derived cells, are physiologically natural and avoid graft-versus-host reactions. However, harvesting autologous cells is invasive, and the cell yield is relatively low.
Biomedicines, 2022 • January 23, 2022
This study aimed to understand the mode of action of human platelet lysate (HPL) during skin-organoid formation and immune modulation by separating extracellular vesicles (EVs) from soluble factors. T...
KEY FINDING: Proteomics showed three major clusters of protein composition separating TSEC-EVs from HPL clustering with TFF soluble fractions and TFF-EVs clustering with TSEC soluble fractions, respectively.
Biomedicines, 2022 • February 1, 2022
This study evaluated the efficacy of neural progenitor cell (NPC) transplantation in a chronic spinal cord injury (SCI) model, focusing on cell survival, differentiation, and axonal regeneration. Diss...
KEY FINDING: Dissociated NPCs (dNPCs) showed better survival and proliferation in the chronic injury environment compared to cultured NPCs (cNPCs).
Biomolecules, 2022 • February 21, 2022
This systematic review and meta-analysis assessed the safety and efficacy of cell-based therapies for neurodegenerative diseases including MS, SCI, PD, and AD. The study analyzed data from 71 records ...
KEY FINDING: The overall frequency of serious adverse events (SAEs) after cell-based treatment was low, approximately 0.03 (95% CI: 0.01–0.08).
Molecules, 2022 • February 21, 2022
This study aimed to develop a biomimetic Bruch’s membrane (BM) using electrospun poly(ε-caprolactone) (PCL) nanofibrous membranes functionalized with integrin-binding peptides (IBPs) to promote retina...
KEY FINDING: IBP coating significantly improved the hydrophilicity of the PCL membranes, making them more favorable for cell attachment.
Bone Research, 2022 • January 17, 2022
The review summarizes the roles of pericytes in spinal cord injury (SCI) and bone repair, highlighting their subtypes, markers, and differentiation potential. Pericytes are crucial for vascular stabil...
KEY FINDING: Pericytes are vital to vascular stability and the regulation of vascular structure, with different subtypes having different effects on blood vessels. PDGFR-β-type pericytes differentiate into smooth muscle cells, while CD146-type pericytes are essential for pericyte recruitment and BBB development.
Wound Rep Reg, 2022 • January 28, 2022
This study investigates the role of the skin microbiome in tail regeneration of Xenopus laevis tadpoles during the refractory period, showing that microbiome composition varies between tadpole sibship...
KEY FINDING: The tadpole skin microbiome varies significantly between sibships and is altered by raising tadpoles in the antibiotic gentamicin.
Scientific Reports, 2022 • February 18, 2022
The study demonstrates that phentolamine treatment enhances functional recovery after peripheral nerve injury (PNI) in mice. This includes improved motor function, protection of axon myelination, and ...
KEY FINDING: Phentolamine treatment significantly enhanced functional recovery in mice at 14 days post-injury (dpi) following peripheral nerve injury, as evidenced by improved rotarod performance and sciatic function index (SFI).
Frontiers in Endocrinology, 2022 • February 17, 2022
This study comprehensively examined and elucidated the pharmacological and physiological regulation of central melanocortin signaling in the axolotl. The study found a relatively conserved protein str...
KEY FINDING: Axolotl MC3R and MC4R can be activated by a-MSH and ACTH. Axolotl MC3R exhibited a high constitutive activity, that was significantly decreased by MRAP2