Regenerative Medicine Research

KEY FINDING: HAP stem cells implanted into the severed spinal cord differentiated into neurons, astrocytes, and oligodendrocytes in both C57BL/6J and nude mice.

KEY FINDING: Co-culturing RECs and nucleus pulposus cells (NPCs) in the gel significantly increased gene expression of NPC markers, growth factors, and extracellular matrix compared to monocultures.

KEY FINDING: Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration, suggesting therapeutic potential in promoting YAP/TAZ signaling to enhance mammalian regeneration.

KEY FINDING: Inpp5k increases axon outgrowth of cortical neurons in vitro by increasing the availability of active nonphosphorylated cofilin within labile axonal growth cones.

KEY FINDING: MaR1 demonstrated a more robust ability to promote sensory and motor function recovery in mice after sciatic nerve crush injury than NGF.

KEY FINDING: MSCs can regulate macrophage polarization, shifting the balance from pro-inflammatory M1 to anti-inflammatory M2 phenotypes, which promotes axonal regeneration and reduces glial scar formation.

KEY FINDING: BMP4 activation can preserve the developmental potential and safeguard the chromosomal integrity of mESCs.

KEY FINDING: ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis in vitro.

KEY FINDING: CSPGs inhibit neurogenesis and synaptogenesis of human drNPC-O2 through activation of LAR and PTPr receptors in vitro.

KEY FINDING: HJ-01 and HJ-02 restore sympathetic axon outgrowth over inhibitory CSPGs in a dose-dependent manner.