Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,241-5,250 of 5,401 results
JOURNAL OF NEUROTRAUMA, 2008 • August 1, 2008
This study investigated the effects of varied implant architectures on spinal cord (SC) regeneration using 3D-printed scaffolds with five different macro-architectures: cylinder, tube, channel, open-p...
KEY FINDING: Open-path scaffold architectures enhanced spinal cord regeneration compared to the three other designs without the use of biological factors.
Exp Neurol, 2008 • November 1, 2008
The study investigates the effects of lumbosacral ventral root avulsion (VRA) injury and re-implantation on the morphology of the rat bladder at twelve weeks post-operatively. VRA injury caused a thin...
KEY FINDING: VRA injury leads to overall thinning of the bladder wall, reduced thickness of the lamina propria and smooth muscle, and increased thickness of the bladder epithelium.
J Cell Sci, 2008 • September 15, 2008
This study demonstrates that specific sulfation in chondroitin sulfate (CS) glycosaminoglycan (GAG) chains mediates neuronal guidance cues and axonal growth inhibition, with chondroitin-4-sulfate (CS-...
KEY FINDING: Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C), exhibits a strong negative guidance cue to mouse cerebellar granule neurons, indicating that sulfation at the C4 position of the GalNAc moiety presents a specific negative guidance cue to axons.
Neurobiol Dis, 2008 • November 1, 2008
This study investigated the effects of Niaspan on EAE mice, demonstrating that Niaspan treatment significantly improves neurological functional recovery. This recovery is potentially mediated by the r...
KEY FINDING: Niaspan treatment significantly increased neurological functional recovery in EAE mice compared to controls.
Neuroscience, 2008 • October 15, 2008
The MRL/MpJ mouse strain, known for its regenerative abilities, was studied after spinal cord injury to see if it would result in reduced scar formation, increased axonal growth, and improved function...
KEY FINDING: MRL/MpJ mice exhibited robust axon growth within the lesion, beginning at 4 weeks post-injury.
The Journal of Neuroscience, 2008 • September 17, 2008
This study demonstrates the critical role of CD11b+ myeloid cells in axon regeneration after neural injury, using a transgenic mouse model for selective cell ablation. The absence of CD11b+ cells lead...
KEY FINDING: Selective ablation of CD11b+ cells impairs axonal regeneration and locomotor function recovery after sciatic nerve injury.
J Neurosci Res, 2009 • February 1, 2009
This study demonstrates that human fetal cortical NSCs can be induced to express spinal motor neuron characteristics in vitro by bFGF. bFGF enhances the expression of ventral markers such as Olig2 in ...
KEY FINDING: bFGF induces human NSCs to express the motor neuron marker Hb9.
Journal of Biology, 2008 • September 19, 2008
This study investigates the effects of transplanting astrocytes derived from glial-restricted precursors (GRPs) treated with bone morphogenetic protein-4 (BMP-4) or ciliary neurotrophic factor (CNTF) ...
KEY FINDING: GDAsBMP promote axon regeneration, neuroprotection and robust recovery of function after spinal cord injury, whereas GDAsCNTF do not.
Neurosci Bull, 2008 • October 1, 2008
This review summarizes the method of cell transplantation via CSF for treatment of SCI. Studies on administration of cells via CSF indicate that the method is safe and convenient. The method is more s...
KEY FINDING: Cell transplantation via CSF is a safe and convenient method for treating SCI, particularly suitable for multiple CNS lesions because it does not involve open lesions.
Journal of Neuroinflammation, 2008 • October 15, 2008
The study investigates the effect of TMEV infection on inflammation and neurogenesis in the SVZ, a key area for brain repair. Results indicated that forebrain CD45+ cell activation precedes spinal cor...
KEY FINDING: CD45+ cell activation occurs early in the forebrain after TMEV infection, with the SVZ showing the most consistent activation.